T lymphocytes redirected against the κ light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells

There has been interest in generating T cells expressing chimeric artificial receptors (CARs) targeting CD19/CD20 antigens to treat B-cell lymphomas. If successful, however, this approach would likely impair humoral immunity because T cells may persist long-term. Most low-grade lymphoma and chronic...

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Autores principales: Vera, Juan, Savoldo, Barbara, Vigouroux, Stephane, Biagi, Ettore, Pule, Martin, Rossig, Claudia, Wu, Jessie, Heslop, Helen E., Rooney, Cliona M., Brenner, Malcolm K., Dotti, Gianpietro
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Hematology 2006
Materias:
Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895462/
https://ncbi.nlm.nih.gov/pubmed/16926291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-017061
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