Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis

Effector-memory T cells expressing Fas (Apo-1/CD95) are switched to an apoptotic program by cross-linking with Fas-ligand (FasL). Consequently, tumors that express FasL can induce apoptosis of infiltrating Fas-positive T lymphocytes and subdue any antitumor host immune response. Since Epstein-Barr v...

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Autors principals: Dotti, Gianpietro, Savoldo, Barbara, Pule, Martin, Straathof, Karin C., Biagi, Ettore, Yvon, Eric, Vigouroux, Stephane, Brenner, Malcolm K., Rooney, Cliona M.
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2005
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895003/
https://ncbi.nlm.nih.gov/pubmed/15713795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-08-3337
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