High-dose factor VIII inhibits factor VIII–specific memory B cells in hemophilia A with factor VIII inhibitors

Hemophilia A in its severe form is a life-threatening hemorrhagic disease that is caused by mutations in the factor VIII (FVIII) gene (symbol F8). About 25% of patients who receive replacement therapy develop neutralizing antibodies that inhibit the function of substituted FVIII. Long-term applicati...

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Bibliographische Detailangaben
Hauptverfasser: Hausl, Christina, Ahmad, Rafi U., Sasgary, Maria, Doering, Christopher B., Lollar, Pete, Richter, Günter, Schwarz, Hans Peter, Turecek, Peter L., Reipert, Birgit M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society of Hematology 2005
Schlagworte:
Hemostasis, Thrombosis, and Vascular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895061/
https://ncbi.nlm.nih.gov/pubmed/16091456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-1182
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