The human DNA repair factor XPC-HR23B distinguishes stereoisomeric benzo[a]pyrenyl-DNA lesions

Benzo[a]pyrene (B[a]P), a known environmental pollutant and tobacco smoke carcinogen, is metabolically activated to highly tumorigenic B[a]P diol epoxide derivatives that predominantly form N(2)-guanine adducts in cellular DNA. Although nucleotide excision repair (NER) is an important cellular defen...

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Main Authors: Mocquet, Vincent, Kropachev, Konstantin, Kolbanovskiy, Marina, Kolbanovskiy, Alexander, Tapias, Angels, Cai, Yuqin, Broyde, Suse, Geacintov, Nicholas E, Egly, Jean-Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1894768/
https://ncbi.nlm.nih.gov/pubmed/17525733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601730
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