Collagen Type II-Specific Monoclonal Antibody-Induced Arthritis in Mice : Description of the Disease and the Influence of Age, Sex, and Genes

Podobne zapisy

• Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells
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• Type IX collagen deficiency enhances the binding of cartilage-specific antibodies and arthritis severity
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• Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen
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• Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis
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• Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice
  od: Lindh, Ingrid, i wsp.
  Wydane: (2014)