Downregulation of tonic GABA currents following epileptogenic stimulation of rat hippocampal cultures

Deficits in GABAergic inhibitory transmission are a hallmark of temporal lobe epilepsy and have been replicated in animal and tissue culture models of epilepsy. GABAergic inhibition comprises phasic and tonic inhibition that is mediated by synaptic and extrasynaptic GABA(A) receptors, respectively....

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Bibliographic Details
Main Authors: Qi, Jin-shun, Yao, Jun, Fang, Cheng, Luscher, Bernhard, Chen, Gong
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2006
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890447/
https://ncbi.nlm.nih.gov/pubmed/16990405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.113134
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