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The antihelminthic moxidectin enhances tonic GABA currents in rodent hippocampal pyramidal neurons

Macrocyclic lactones (MLs) are commonly used treatments for parasitic worm and insect infections in humans, livestock, and companion animals. MLs target the invertebrate glutamate-activated chloride channel that is not present in vertebrates. MLs are not entirely inert in vertebrates, though; they h...

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Bibliographic Details
Published in:J Neurophysiol
Main Authors: Spampanato, Jay, Gibson, Anne, Dudek, F. Edward
Format: Artigo
Language:Inglês
Published: American Physiological Society 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008095/
https://ncbi.nlm.nih.gov/pubmed/29364072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00587.2017
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