Tonic GABA(A) conductance decreases membrane time constant and increases EPSP-spike precision in hippocampal pyramidal neurons

Because of a complex dendritic structure, pyramidal neurons have a large membrane surface relative to other cells and so a large electrical capacitance and a large membrane time constant (τ(m)). This results in slow depolarizations in response to excitatory synaptic inputs, and consequently increase...

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Main Authors: Wlodarczyk, Agnieszka I., Xu, Chun, Song, Inseon, Doronin, Maxim, Wu, Yu-Wei, Walker, Matthew C., Semyanov, Alexey
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2013
主題:
Neuroscience
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3872325/
https://ncbi.nlm.nih.gov/pubmed/24399937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncir.2013.00205
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