A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate.

Multiple human cytomegalovirus (HCMV) strains frequently coexist in patients with AIDS, and chronic ganciclovir treatment may favor the emergence of ganciclovir-resistant viral mutants. We report the molecular and biochemical characterization of a HCMV ganciclovir-resistant strain (VR3480) previousl...

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Détails bibliographiques
Auteurs principaux: Baldanti, F, Silini, E, Sarasini, A, Talarico, C L, Stanat, S C, Biron, K K, Furione, M, Bono, F, Palù, G, Gerna, G
Format: Artigo
Langue:Inglês
Publié: 1995
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC188644/
https://ncbi.nlm.nih.gov/pubmed/7815545
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