A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.

Ganciclovir-resistant mutant 759rD100 derived from human cytomegalovirus strain AD169 contains two resistance mutations, one of which is in the UL97 gene and results in decreased ganciclovir phosphorylation in infected cells [V. Sullivan, C. L. Talarico, S. C. Stanat, M. Davis, D. M. Coen, and K. K....

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Sullivan, V, Biron, K K, Talarico, C, Stanat, S C, Davis, M, Pozzi, L M, Coen, D M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187598/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8381637/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.1.19
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