The Cys607→Tyr Change in the UL97 Phosphotransferase Confers Ganciclovir Resistance to Two Human Cytomegalovirus Strains Recovered from Two Immunocompromised Patients

Two ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) strains recovered from an AIDS patient (strain VR4990) and a heart transplant recipient (strain VR5474) showed a Cys607→Tyr change in the UL97-encoded phosphotransferase. No amino acid substitutions were observed in the viral DNA polymeras...

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Detalhes bibliográficos
Main Authors: Baldanti, Fausto, Underwood, Mark R., Talarico, Christine L., Simoncini, Lavinia, Sarasini, Antonella, Biron, Karen K., Gerna, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC105432/
https://ncbi.nlm.nih.gov/pubmed/9527804
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