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The Cys607→Tyr Change in the UL97 Phosphotransferase Confers Ganciclovir Resistance to Two Human Cytomegalovirus Strains Recovered from Two Immunocompromised Patients

Two ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) strains recovered from an AIDS patient (strain VR4990) and a heart transplant recipient (strain VR5474) showed a Cys607→Tyr change in the UL97-encoded phosphotransferase. No amino acid substitutions were observed in the viral DNA polymeras...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Baldanti, Fausto, Underwood, Mark R., Talarico, Christine L., Simoncini, Lavinia, Sarasini, Antonella, Biron, Karen K., Gerna, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1998
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105432/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9527804/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.2.444
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