Steady-state pharmacokinetics, pharmacodynamics and tolerability of donepezil hydrochloride in hepatically impaired patients

AIMS: To evaluate the pharmacokinetics (PK), pharmacodynamics (PD), tolerability and safety of donepezil HCl 5 mg following oral doses for 1 and 24 days in hepatically impaired patients compared with healthy controls under steady-state, multiple-dose conditions. METHODS: In this single-centre, multi...

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Bibliographic Details
Main Authors: Reyes, Josephine F, Vargas, Ramon, Kumar, Dinesh, Cullen, Edward I, Perdomo, Carlos A, Pratt, Raymond D
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2004
Subjects:
The clinical pharmacokinetics and safety of donepezil: an update Guest Editors: Stephen Jackson & Roy Jones
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884555/
https://ncbi.nlm.nih.gov/pubmed/15496218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.01802.x
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