Concurrent administration of donepezil HCl and levodopa/carbidopa in patients with Parkinson's disease: assessment of pharmacokinetic changes and safety following multiple oral doses

AIM: The use of acetylcholinesterase inhibitors for the treatment of comorbid Alzheimer's disease in Parkinson's disease (PD) patients stabilized on a levodopa regimen may potentially disrupt cholinergic balance. This randomized, double-blind, crossover study investigated the safety of, an...

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Autores principales: Okereke, Chukwuemeka S, Kirby, Louis, Kumar, Dinesh, Cullen, Edward I, Pratt, Raymond D, Hahne, William A
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2004
Materias:
The clinical pharmacokinetics and safety of donepezil: an update Guest Editors: Stephen Jackson & Roy Jones
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884553/
https://ncbi.nlm.nih.gov/pubmed/15496222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.01799.x
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