Concurrent administration of donepezil HCl and sertraline HCl in healthy volunteers: assessment of pharmacokinetic changes and safety following single and multiple oral doses

AIM: This study evaluated the safety and pharmacokinetics (PK) of donepezil HCl and sertraline HCl when administered separately and in combination. METHODS: This was a randomized, open-label, three-period crossover study. In consecutive dosing periods separated by washout periods of ≥3 weeks, health...

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Autores principales: Nagy, Christa F, Kumar, Dinesh, Perdomo, Carlos A, Wason, Suman, Cullen, Edward I, Pratt, Raymond D
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2004
Materias:
The clinical pharmacokinetics and safety of donepezil: an update Guest Editors: Stephen Jackson & Roy Jones
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884554/
https://ncbi.nlm.nih.gov/pubmed/15496220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.01801.x
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