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Tizanidine is mainly metabolized by cytochrome P450 1A2 in vitro

AIMS: To identify the cytochrome P450 (CYP) enzyme(s) that catalyze the metabolism of tizanidine in vitro. METHODS: The effect of CYP isoform inhibitors on the elimination of tizanidine was studied using pooled human liver microsomes. The metabolism of the drug by a range of human recombinant CYP is...

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Detalhes bibliográficos
Main Authors: Granfors, Marika T, Backman, Janne T, Laitila, Jouko, Neuvonen, Pertti J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884447/
https://ncbi.nlm.nih.gov/pubmed/14998432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.02028.x
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