In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9)

AIMS: To evaluate the potency and specificity of valproic acid as an inhibitor of the activity of different human CYP isoforms in liver microsomes. METHODS: Using pooled human liver microsomes, the effects of valproic acid on seven CYP isoform specific marker reactions were measured: phenacetin O-de...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wen, Xia, Wang, Jun-Sheng, Kivistö, Kari T, Neuvonen, Pertti J, Backman, Janne T
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Science Inc 2001
Pynciau:
Drug Interactions
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014611/
https://ncbi.nlm.nih.gov/pubmed/11736863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01474.x
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