Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects

AIMS: Case reports suggest an interaction between rofecoxib and the CYP1A2 substrate tizanidine. Our objectives were to explore the extent and mechanism of this possible interaction and to determine the CYP1A2 inhibitory potency of rofecoxib. METHODS: In a randomized, double-blind, two-phase cross-o...

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Bibliografske podrobnosti
Main Authors: Backman, Janne T, Karjalainen, Marjo J, Neuvonen, Mikko, Laitila, Jouko, Neuvonen, Pertti J
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2006
Teme:
Drug Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885136/
https://ncbi.nlm.nih.gov/pubmed/16934051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02653.x
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