Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects

AIMS: Case reports suggest an interaction between rofecoxib and the CYP1A2 substrate tizanidine. Our objectives were to explore the extent and mechanism of this possible interaction and to determine the CYP1A2 inhibitory potency of rofecoxib. METHODS: In a randomized, double-blind, two-phase cross-o...

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Bibliographic Details
Main Authors: Backman, Janne T, Karjalainen, Marjo J, Neuvonen, Mikko, Laitila, Jouko, Neuvonen, Pertti J
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2006
Subjects:
Drug Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885136/
https://ncbi.nlm.nih.gov/pubmed/16934051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02653.x
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