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Tizanidine is mainly metabolized by cytochrome P450 1A2 in vitro
AIMS: To identify the cytochrome P450 (CYP) enzyme(s) that catalyze the metabolism of tizanidine in vitro. METHODS: The effect of CYP isoform inhibitors on the elimination of tizanidine was studied using pooled human liver microsomes. The metabolism of the drug by a range of human recombinant CYP is...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Blackwell Science Inc
2004
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1884447/ https://ncbi.nlm.nih.gov/pubmed/14998432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.02028.x |
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