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Nootropic α7 nicotinic receptor allosteric modulator derived from GABA(A) receptor modulators

Activation of brain α7 nicotinic acetylcholine receptors (α7 nAChRs) has broad therapeutic potential in CNS diseases related to cognitive dysfunction, including Alzheimer's disease and schizophrenia. In contrast to direct agonist activation, positive allosteric modulation of α7 nAChRs would del...

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Detalhes bibliográficos
Main Authors: Ng, Herman J., Whittemore, Edward R., Tran, Minhtam B., Hogenkamp, Derk J., Broide, Ron S., Johnstone, Timothy B., Zheng, Lijun, Stevens, Karen E., Gee, Kelvin W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876571/
https://ncbi.nlm.nih.gov/pubmed/17470817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701321104
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