Nootropic α7 nicotinic receptor allosteric modulator derived from GABA(A) receptor modulators

Activation of brain α7 nicotinic acetylcholine receptors (α7 nAChRs) has broad therapeutic potential in CNS diseases related to cognitive dysfunction, including Alzheimer's disease and schizophrenia. In contrast to direct agonist activation, positive allosteric modulation of α7 nAChRs would del...

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Main Authors: Ng, Herman J., Whittemore, Edward R., Tran, Minhtam B., Hogenkamp, Derk J., Broide, Ron S., Johnstone, Timothy B., Zheng, Lijun, Stevens, Karen E., Gee, Kelvin W.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876571/
https://ncbi.nlm.nih.gov/pubmed/17470817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701321104
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