Design, Synthesis and Activity of a Series of Arylpyrid-3-ylmethanones as Type I Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors

A series of novel arylpyrid-3-ylmethanones (7a-aa) were designed as modulators of α7 nicotinic acetylcholine receptors (nAChRs). The methanones were found to be Type I positive allosteric modulators (PAMs) of human α7 nAChRs expressed in Xenopus ooctyes. Structure activity relationship (SAR) studies...

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Main Authors: Hogenkamp, Derk J., Ford-Hutchinson, Thomas A., Li, Wen-Yen, Whittemore, Edward R., Yoshimura, Ryan F., Tran, Minhtam B., Johnstone, Timothy B. C., Bascom, Gavin D., Rollins, Hannah, Lu, Lena, Gee, Kelvin W.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912855/
https://ncbi.nlm.nih.gov/pubmed/24098954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400704g
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