Allosteric Modulation of Related Ligand-Gated Ion Channels Synergistically Induces Long-Term Potentiation in the Hippocampus and Enhances Cognition

α5 Subunit-containing GABA(A) receptors (GABA(A)Rs) and α7 neuronal nicotinic-acetylcholine receptors (nAChRs) are members of the Cys-loop family of ligand-gated ion channels (LGICs) that mediate cognitive and attentional processes in the hippocampus. α5 GABA(A)Rs alter network activity by tonic inh...

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Bibliographische Detailangaben
Hauptverfasser: Johnstone, Timothy B., Gu, Zhenglin, Yoshimura, Ryan F., Villegier, Anne-Sophie, Hogenkamp, Derk J., Whittemore, Edward R., Huang, Jin-Cheng, Tran, Minhtam B., Belluzzi, James D., Yakel, Jerrel L., Gee, Kelvin W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2011
Schlagworte:
Drug Discovery and Translational Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061525/
https://ncbi.nlm.nih.gov/pubmed/21159751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.176255
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