Positive allosteric modulators of non-benzodiazepine γ-aminobutyric acid(A) receptor subtypes for the treatment of chronic pain

Chronic neuropathic pain may be caused, in part, by loss of inhibition in spinal pain processing pathways due to attenuation of local GABAergic tone. Nociception and nocifensive behaviors are reduced after enhancement of tonically activated extrasynaptic GABA(A)R mediated currents by agonist ligands...

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Vydáno v:Pain
Hlavní autoři: Johnstone, Timothy B.C., Xie, Jennifer Y., Qu, Chaoling, Wasiak, David J., Hogenkamp, Derk J, Porreca, Frank, Gee, Kelvin W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309939/
https://ncbi.nlm.nih.gov/pubmed/30204648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000001392
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