Enaminone Modulators of Extrasynaptic α(4)β(3)δ γ-Aminobutyric Acid(A) Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning

Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABA(A)Rs) that rapidly internalize during status epilepticus (SE). Extrasynaptic GABA(A)Rs, such as those containing α(4...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Johnstone, Timothy B. C., McCarren, Hilary S., Spampanato, Jay, Dudek, F. Edward, McDonough, John H., Hogenkamp, Derk, Gee, Kelvin W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6543275/
https://ncbi.nlm.nih.gov/pubmed/31178732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00560
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados