Enaminone Modulators of Extrasynaptic α(4)β(3)δ γ-Aminobutyric Acid(A) Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning

Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABA(A)Rs) that rapidly internalize during status epilepticus (SE). Extrasynaptic GABA(A)Rs, such as those containing α(4...

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書目詳細資料
發表在:Front Pharmacol
Main Authors: Johnstone, Timothy B. C., McCarren, Hilary S., Spampanato, Jay, Dudek, F. Edward, McDonough, John H., Hogenkamp, Derk, Gee, Kelvin W.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2019
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6543275/
https://ncbi.nlm.nih.gov/pubmed/31178732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00560
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