Validating a model of benzodiazepine refractory nerve agent-induced status epilepticus by evaluating the anticonvulsant and neuroprotective effects of scopolamine, memantine, and phenobarbital

INTRODUCTION: Organophosphorus nerve agents (OPNAs) irreversibly block acetylcholinesterase activity, resulting in accumulation of excess acetylcholine at neural synapses, which can lead to a state of prolonged seizures known as status epilepticus (SE). Benzodiazepines, the current standard of care...

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Veröffentlicht in:J Pharmacol Toxicol Methods
Hauptverfasser: Jackson, Cecelia, Ardinger, Cherish, Winter, Kristin M., McDonough, John H., McCarren, Hilary S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529248/
https://ncbi.nlm.nih.gov/pubmed/30790623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vascn.2019.02.006
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