Positive allosteric modulators of non-benzodiazepine γ-aminobutyric acid(A) receptor subtypes for the treatment of chronic pain

Chronic neuropathic pain may be caused, in part, by loss of inhibition in spinal pain processing pathways due to attenuation of local GABAergic tone. Nociception and nocifensive behaviors are reduced after enhancement of tonically activated extrasynaptic GABA(A)R mediated currents by agonist ligands...

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Publicado en:Pain
Autores principales: Johnstone, Timothy B.C., Xie, Jennifer Y., Qu, Chaoling, Wasiak, David J., Hogenkamp, Derk J, Porreca, Frank, Gee, Kelvin W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309939/
https://ncbi.nlm.nih.gov/pubmed/30204648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000001392
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