Realising the therapeutic potential of neuroactive steroid modulators of the GABA(A) receptor

In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABA(A) receptor (GABA(A)R). These reports were followed by the discovery that such steroids may be synthesised not only in...

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Detalhes bibliográficos
Publicado no:Neurobiol Stress
Main Authors: Belelli, Delia, Hogenkamp, Derk, Gee, Kelvin W., Lambert, Jeremy J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Articles from the Special Issue on Allopregnanolone role in the neurobiology of stress and mood disorders; Edited by Graziano Pinna
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7231973/
https://ncbi.nlm.nih.gov/pubmed/32435660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ynstr.2019.100207
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