GABA(A) and glycine receptor-mediated transmission in rat lamina II neurones: relevance to the analgesic actions of neuroactive steroids

Analgesic neurosteroids such as 5α-pregnan-3α-ol-20-one (5α3α) are potent selective endogenous modulators of the GABA(A) receptor (GABA(A)R) while certain synthetic derivatives (i.e. minaxolone) additionally enhance the function of recombinant glycine receptors (GlyR). Inhibitory transmission within...

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Hlavní autoři: Mitchell, Elizabeth A, Gentet, Luc J, Dempster, John, Belelli, Delia
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2007
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2277187/
https://ncbi.nlm.nih.gov/pubmed/17656439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.134445
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