Allele-Specific Polymerase Chain Reaction for the Imatinib-Resistant KIT D816V and D816F Mutations in Mastocytosis and Acute Myelogenous Leukemia

Oncogenic mutations of the receptor tyrosine kinase KIT contribute to the pathogenesis of gastrointestinal stromal tumors, systemic mastocytosis (SM), and some cases of acute myelogenous leukemia (AML). The D816V substitution in the activation loop of KIT results in relative resistance to the kinase...

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Autors principals: Corless, Christopher L., Harrell, Patina, Lacouture, Mario, Bainbridge, Troy, Le, Claudia, Gatter, Ken, White, Clifton, Granter, Scott, Heinrich, Michael C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2006
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876167/
https://ncbi.nlm.nih.gov/pubmed/17065430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2006.060089
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