Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

In Huntington's disease (HD), mutation of huntingtin causes selective neurodegeneration of dopaminoceptive striatal medium spiny neurons. Transgenic HD model mice that express a portion of the disease-causing form of human huntingtin develop a behavioral phenotype that suggests dysfunction of dopami...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Bibb, James A., Yan, Zhen, Svenningsson, Per, Snyder, Gretchen L., Pieribone, Vincent A., Horiuchi, Atsuko, Nairn, Angus C., Messer, Anne, Greengard, Paul
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2000
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18747/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10829080/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.120166397
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