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Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

In Huntington's disease (HD), mutation of huntingtin causes selective neurodegeneration of dopaminoceptive striatal medium spiny neurons. Transgenic HD model mice that express a portion of the disease-causing form of human huntingtin develop a behavioral phenotype that suggests dysfunction of dopami...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Bibb, James A., Yan, Zhen, Svenningsson, Per, Snyder, Gretchen L., Pieribone, Vincent A., Horiuchi, Atsuko, Nairn, Angus C., Messer, Anne, Greengard, Paul
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18747/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10829080/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.120166397
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