Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

In Huntington's disease (HD), mutation of huntingtin causes selective neurodegeneration of dopaminoceptive striatal medium spiny neurons. Transgenic HD model mice that express a portion of the disease-causing form of human huntingtin develop a behavioral phenotype that suggests dysfunction of dopami...

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Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Bibb, James A., Yan, Zhen, Svenningsson, Per, Snyder, Gretchen L., Pieribone, Vincent A., Horiuchi, Atsuko, Nairn, Angus C., Messer, Anne, Greengard, Paul
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18747/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10829080/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.120166397
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