Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

In Huntington's disease (HD), mutation of huntingtin causes selective neurodegeneration of dopaminoceptive striatal medium spiny neurons. Transgenic HD model mice that express a portion of the disease-causing form of human huntingtin develop a behavioral phenotype that suggests dysfunction of dopami...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bibb, James A., Yan, Zhen, Svenningsson, Per, Snyder, Gretchen L., Pieribone, Vincent A., Horiuchi, Atsuko, Nairn, Angus C., Messer, Anne, Greengard, Paul
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18747/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10829080/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.120166397
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