Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

In Huntington's disease (HD), mutation of huntingtin causes selective neurodegeneration of dopaminoceptive striatal medium spiny neurons. Transgenic HD model mice that express a portion of the disease-causing form of human huntingtin develop a behavioral phenotype that suggests dysfunction of dopami...

詳細記述

書誌詳細

出版年:	Proc Natl Acad Sci U S A
主要な著者:	Bibb, James A., Yan, Zhen, Svenningsson, Per, Snyder, Gretchen L., Pieribone, Vincent A., Horiuchi, Atsuko, Nairn, Angus C., Messer, Anne, Greengard, Paul
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 2000
主題:	Biological Sciences
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18747/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10829080/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.120166397
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