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Reversible gene knockdown in mice using a tight, inducible shRNA expression system

RNA interference through expression of short hairpin (sh)RNAs provides an efficient approach for gene function analysis in mouse genetics. Techniques allowing to control time and degree of gene silencing in vivo, however, are still lacking. Here we provide a generally applicable system for the tempo...

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Détails bibliographiques
Auteurs principaux: Seibler, Jost, Kleinridders, Andre, Küter-Luks, Birgit, Niehaves, Sandra, Brüning, Jens C., Schwenk, Frieder
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874634/
https://ncbi.nlm.nih.gov/pubmed/17376804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm122
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