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Inhibiting autophagy by shRNA knockdown: Cautions and recommendations

A glance through Autophagy or any other journal in this field shows that it is very common to block autophagy by RNA interference-based knockdown of ATG mRNAs in mammalian cell lines. Our lab’s experience is that this approach can easily make for failed experiments because good knockdown of even ess...

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Hlavní autoři: Staskiewicz, Leah, Thorburn, Jacqueline, Morgan, Michael J, Thorburn, Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974882/
https://ncbi.nlm.nih.gov/pubmed/23800703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.24895
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