Inducible Transgenic Rat Model for Diabetes Mellitus Based on shRNA-Mediated Gene Knockdown

The rat is an important animal model in biomedical research, but gene targeting technology is not established for this species. Therefore, we aimed to produce transgenic knockdown rats using shRNA technology and pronuclear microinjection. To this purpose, we employed a tetracycline-inducible shRNA e...

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Bibliographic Details
Main Authors: Kotnik, Katarina, Popova, Elena, Todiras, Mihail, Mori, Marcelo A., Alenina, Natalia, Seibler, Jost, Bader, Michael
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659743/
https://ncbi.nlm.nih.gov/pubmed/19340286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005124
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