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Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats
Currently, tools to generate loss-of-function mutations in rats are limited. Therefore, we have developed a lentiviral single-vector system for the temporal control of ubiquitous shRNA expression. Here, we report transgenic rats carrying an insulin receptor-specific shRNA transcribed from a regulata...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587564/ https://ncbi.nlm.nih.gov/pubmed/19017805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806213105 |
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