A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels

Plasma factor VIII coagulant activity (FVIII:C) level is a highly heritable quantitative trait that is strongly correlated with thrombosis risk. Polymorphisms within only 1 gene, the ABO blood-group locus, have been unequivocally demonstrated to contribute to the broad population variability observe...

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Detalhes bibliográficos
Main Authors: Viel, Kevin R., Machiah, Deepa K., Warren, Diane M., Khachidze, Manana, Buil, Alfonso, Fernstrom, Karl, Souto, Juan C., Peralta, Juan M., Smith, Todd, Blangero, John, Porter, Sandra, Warren, Stephen T., Fontcuberta, Jordi, Soria, Jose M., Dana Flanders, W., Almasy, Laura, Howard, Tom E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874571/
https://ncbi.nlm.nih.gov/pubmed/17209060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-026104
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