Absence of functional compensation between coagulation factor VIII and plasminogen in double-knockout mice

Plasminogen deficiency is associated with severely compromised fibrinolysis and extravascular deposition of fibrin. In contrast, coagulation factor VIII (FVIII) deficiency leads to prolonged and excessive bleeding. Based on opposing biological functions of plasminogen and FVIII deficiencies, we hypo...

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Detalhes bibliográficos
Publicado no:Blood Adv
Principais autores: Stagaard, Rikke, Ley, Carsten Dan, Almholt, Kasper, Olsen, Lisbeth Høier, Knudsen, Tom, Flick, Matthew J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258924/
https://ncbi.nlm.nih.gov/pubmed/30459211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018024851
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