Structure of blood coagulation factor VIII in complex with an anti–C1 domain pathogenic antibody inhibitor

Antibody inhibitor development in hemophilia A represents the most significant complication resulting from factor VIII (fVIII) replacement therapy. Recent studies have demonstrated that epitopes present in the C1 domain contribute to a pathogenic inhibitor response. In this study, we report the stru...

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Vydáno v:Blood
Hlavní autoři: Gish, Joseph S., Jarvis, Lexi, Childers, Kenneth C., Peters, Shaun C., Garrels, Connor S., Smith, Ian W., Spencer, H. Trent, Doering, Christopher B., Lollar, Pete, Spiegel, P. Clint
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2021
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8160500/
https://ncbi.nlm.nih.gov/pubmed/33529335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020008940
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