Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy

The accumulation of insoluble protein aggregates in intra and perinuclear inclusions is a hallmark of Huntington's disease (HD) and related glutamine-repeat disorders. A central question is whether protein aggregation plays a direct role in the pathogenesis of these neurodegenerative diseases....

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Main Authors: Heiser, Volker, Scherzinger, Eberhard, Boeddrich, Annett, Nordhoff, Eckhard, Lurz, Rudi, Schugardt, Nancy, Lehrach, Hans, Wanker, Erich E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2000
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC18723/
https://ncbi.nlm.nih.gov/pubmed/10829068
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