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Stabilizing IκBα by ‘consensus’ design
IκBα is the major regulator of transcription factor NF-κB function. The ankyrin repeat region of IκBα mediates specific interactions with NF-κB dimers, but ankyrin repeats 1, 5 and 6 display a highly dynamic character when not in complex with NF-κB. Using chemical denaturation, we show here that IκB...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1866275/ https://ncbi.nlm.nih.gov/pubmed/17174335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.11.044 |
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