Stabilizing IκBα by ‘consensus’ design

IκBα is the major regulator of transcription factor NF-κB function. The ankyrin repeat region of IκBα mediates specific interactions with NF-κB dimers, but ankyrin repeats 1, 5 and 6 display a highly dynamic character when not in complex with NF-κB. Using chemical denaturation, we show here that IκB...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ferreiro, Diego U., Cervantes, Carla F., Truhlar, Stephanie M. E., Cho, Samuel S., Wolynes, Peter G., Komives, Elizabeth A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2006
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866275/
https://ncbi.nlm.nih.gov/pubmed/17174335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.11.044
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