Characterization of in vitro and in vivo hypomethylating effects of decitabine in acute myeloid leukemia by a rapid, specific and sensitive LC-MS/MS method

DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents (e.g., decitabine). Detection of changes in DNA methylation might serve as a pharmacodynamic endpoint to establish the biological activity of these agents and predict...

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Detalhes bibliográficos
Main Authors: Liu, Zhongfa, Liu, Shujun, Xie, Zhiliang, Blum, William, Perrotti, Danilo, Paschka, Peter, Klisovic, Rebecca, Byrd, John, Chan, Kenneth K., Marcucci, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865075/
https://ncbi.nlm.nih.gov/pubmed/17264127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl1156
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