In Vivo Quantification of Active Decitabine-Triphosphate Metabolite: A Novel Pharmacoanalytical Endpoint for Optimization of Hypomethylating Therapy in Acute Myeloid Leukemia

Decitabine (DAC) is used for treatment of patients with myelodysplastic syndromes and acute myeloid leukemia (AML). Following cellular uptake, DAC is activated to DAC-triphosphate (TP) and incorporated into DNA. Once incorporated into the DNA, DAC-TP binds and inactivates DNA methyltransferases (DNM...

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Main Authors: Wang, Hongyan, Chen, Ping, Wang, Jiang, Santhanam, Ramasamy, Aimiuwu, Josephine, Saradhi, U. V. Vijaya, Liu, Zhongfa, Schwind, Sebastian, Mims, Alice, Byrd, John C., Grever, Michael R., Villalona-Calero, Miguel A., Klisovic, Rebecca, Walker, Alison, Garzon, Ramiro, Blum, William, Chan, Kenneth K., Marcucci, Guido
פורמט: Artigo
שפה:Inglês
יצא לאור: Springer US 2012
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535094/
https://ncbi.nlm.nih.gov/pubmed/23180159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9427-5
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