In Vivo Quantification of Active Decitabine-Triphosphate Metabolite: A Novel Pharmacoanalytical Endpoint for Optimization of Hypomethylating Therapy in Acute Myeloid Leukemia

Decitabine (DAC) is used for treatment of patients with myelodysplastic syndromes and acute myeloid leukemia (AML). Following cellular uptake, DAC is activated to DAC-triphosphate (TP) and incorporated into DNA. Once incorporated into the DNA, DAC-TP binds and inactivates DNA methyltransferases (DNM...

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Bibliographic Details
Main Authors: Wang, Hongyan, Chen, Ping, Wang, Jiang, Santhanam, Ramasamy, Aimiuwu, Josephine, Saradhi, U. V. Vijaya, Liu, Zhongfa, Schwind, Sebastian, Mims, Alice, Byrd, John C., Grever, Michael R., Villalona-Calero, Miguel A., Klisovic, Rebecca, Walker, Alison, Garzon, Ramiro, Blum, William, Chan, Kenneth K., Marcucci, Guido
Format: Artigo
Language:Inglês
Published: Springer US 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535094/
https://ncbi.nlm.nih.gov/pubmed/23180159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9427-5
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