In Vivo Quantification of Active Decitabine-Triphosphate Metabolite: A Novel Pharmacoanalytical Endpoint for Optimization of Hypomethylating Therapy in Acute Myeloid Leukemia

Decitabine (DAC) is used for treatment of patients with myelodysplastic syndromes and acute myeloid leukemia (AML). Following cellular uptake, DAC is activated to DAC-triphosphate (TP) and incorporated into DNA. Once incorporated into the DNA, DAC-TP binds and inactivates DNA methyltransferases (DNM...

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Bibliografische gegevens
Hoofdauteurs: Wang, Hongyan, Chen, Ping, Wang, Jiang, Santhanam, Ramasamy, Aimiuwu, Josephine, Saradhi, U. V. Vijaya, Liu, Zhongfa, Schwind, Sebastian, Mims, Alice, Byrd, John C., Grever, Michael R., Villalona-Calero, Miguel A., Klisovic, Rebecca, Walker, Alison, Garzon, Ramiro, Blum, William, Chan, Kenneth K., Marcucci, Guido
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer US 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535094/
https://ncbi.nlm.nih.gov/pubmed/23180159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9427-5
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