Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

Neural stem cells, which exhibit self-renewal and multipotentiality, are generated in early embryonic brains and maintained throughout the lifespan. The mechanisms of their generation and maintenance are largely unknown. Here, we show that neural stem cells are generated independent of RBP-Jκ, a key...

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Bibliografiska uppgifter
Huvudupphovsmän: Hitoshi, Seiji, Alexson, Tania, Tropepe, Vincent, Donoviel, Dorit, Elia, Andrew J., Nye, Jeffrey S., Conlon, Ronald A., Mak, Tak W., Bernstein, Alan, van der Kooy, Derek
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2002
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC186324/
https://ncbi.nlm.nih.gov/pubmed/11937492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.975202
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