Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling

Basic fibroblast growth factor (FGF2)-responsive definitive neural stem cells first appear in embryonic day 8.5 (E8.5) mouse embryos, but not in earlier embryos, although neural tissue exists at E7.5. Here, we demonstrate that leukemia inhibitory factor-dependent (but not FGF2-dependent) sphere-form...

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Detalhes bibliográficos
Main Authors: Hitoshi, Seiji, Seaberg, Raewyn M., Koscik, Cheryl, Alexson, Tania, Kusunoki, Susumu, Kanazawa, Ichiro, Tsuji, Shoji, van der Kooy, Derek
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC517401/
https://ncbi.nlm.nih.gov/pubmed/15289455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1208404
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