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VEGF, a prosurvival factor, acts in concert with TGF-β1 to induce endothelial cell apoptosis
VEGF and TGF-β1 are potent angiogenesis inducers with opposing effects on endothelial cells. TGF-β1 induces apoptosis; VEGF protects endothelial cells from apoptosis. We found that TGF-β1 promotes endothelial cell expression of FGF-2, which up-regulates VEGF synthesis. Inhibition of VEGF signaling t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1859920/ https://ncbi.nlm.nih.gov/pubmed/17088559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605556103 |
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